microRNAs array of livers from three different lifestyle modification mice models

To investigate the microRNAs involved in the processes of beneficial and detrimental lifestyles, including caloric restriction(CR), exercise and high-fat diet(HF), we performed a comprehensive and thorough comparison of microRNAs expression profiles in liver among these lifestyle modifications. We set male C57BL/6 mice at two months of age into the following groups and treated for 3 months: ad libitum, normal-fat diet group (AL); ad libitum, high-fat diet group (HF); normal-fat diet and 30~35% caloric restriction as in AL group (CR); and ad libitum, normal-fat diet with exercise (EX). After the treatment, we applied the microRNA array detection of livers.