Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion. Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA862080
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资源简介：
Whether or not human Tregs are susceptible to exhaustion, and if so, if this would limit their therapeutic effect, was unknown. We studied how a tonic-signaling CAR, which induces Tconv exhaustion, affects human Tregs. We thus sorted naïve Tregs and naïve conventional CD4s and transduced them with a non-TS CAR (CD19) or a TS-CAR (HA). Overall design: 3 TCONV CD19 CAR samples, 4 TCONV HA CAR samples, 5 TREG CD19 CAR samples, 5 TREG HA CAR samples
创建时间：
2022-07-25
