Transcriptome profiling of lung tissue from influenza-infected mice treated with plasma gelsolin

Recombinant human plasma gelsolin (rhu-pGSN) improves survival and reduces morbidity of mice infected with influenza. The goal of this study was to investigate the transcriptome profile of lung tissue from infected mice, treated with either rhu-pGSN or vehicle. Mice were infected intranasally with H1N1 (A/Puerto Rico/8/1934) and treated by subcutaneous injections with rhu-pGSN or vehicle daily starting on day 7 after infection. Lung tissue was harvested on days 7 and 9 for RNA analysis.