Transmission of variant and sporadic CJD cases to tg650 mice expressing human PrP.

na, not available; Fr, French; UK, United Kingdom
1Intracerebral inoculation with 2 mg brain tissue equivalent; n/n0: diseased, PrPres positive/inoculated animals.
2Two tg650 mice died of intercurrent disease at 166 and 274 days but were PrPvCJD positive in both brain and spleen.
3Done in two independent experiments (different schedule and homogenate batch), of which the results are pooled for the sake of clarity.
4One tg650 mouse that succumbed with disease at 437 days had a mixed PrPres profile (Figure S4) and was included for calculation of both survival times.
51st passage performed on hemizygous mice.
6One tg650 mouse died of intercurrent disease at 411 days, but was PrPvCJD positive both in brain and spleen.
7All mice and half of the mice accumulated vCJD-like PrPres in their spleen on 1st and 2nd passage, respectively. The others were negative.
8neg: negative.
9Patient with no TSE disease.