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Highly Efficient Synthesis of Functionalized Indolizines and Indolizinones by Copper-Catalyzed Cycloisomerizations of Propargylic Pyridines

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Highly_Efficient_Synthesis_of_Functionalized_Indolizines_and_Indolizinones_by_Copper_Catalyzed_Cycloisomerizations_of_Propargylic_Pyridines/2983375
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资源简介:
The copper-catalyzed cycloisomerizations of 2-pyridyl-substituted propargylic acetates and its derivatives are described, which offer an efficient route to C-1 oxygenated indolizines with a wide range of substituents under mild reaction conditions. The presented method could be readily applied to the synthesis of indolizinones through a cyclization/1,2-migration of tertiary propargylic alcohols.
创建时间:
2016-06-03
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