The protective effects of GM-0111 against LL-37 induced cystitis are more powerful than other GAG compounds.

The animals receiving each compound at 10/mL dosage by intravesical instillation prior to LL-37 instillation showed variable responses in clinical signs of IC and decreased molecular markers in the serum and tissues. Only the animals treated with GM-0111 were effectively protected from the LL-37 challenge. *p<0.05, **p<0.01, and ***p<0.001 compared to either normal or PBS/LL-37 instilled control group. NS, not significant (p>0.05) by Dunnet’s t-test. Black horizontal bars are mean or median (necropsy and histology scores) values. BDL and the values in the parenthesis represent the number of samples that fell below the detection limit (red dotted line) of the ELISA out of the total samples tested. For data analysis purposes, any values below the detection limit were listed as being at the detection limit, which may in some cases overestimate the numerical value. Gray area represents the range of values found in normal animals.