Supplementary tables - Role of nucleic acid-based polymeric micelles in treating lung diseases

The prevalence of lung diseases is increasing year by year and existing drug therapies only provide
symptomatic relief rather than targeting the actual cause. Nucleic acids can be used as an alternative
therapeutic approach owing to their potential to reform a homeostatic balance by upregulating
protective genes or downregulating damaging genes. However, their inherent properties, such as poor
stability, ineffective cellular uptake, negative charge and so on, hinder their clinical utility. Such limitations
can be overcome by exploiting the functional chemistry of polymeric micelles (PMs) for site-specific
delivery, transfection efficiency and improved stability. With this objective, the present work describes
the advancements made in designing nucleic acid-based PMs for treating lung diseases followed by
approaches requiring consideration for clinical applications.