Molecular targets of HIV integrase inhibitor, MK-2048, on ATL cells

Adult T-cell Leukemia (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes, associated with retrovirus human T-cell leukemia virus type I (HTLV-1). To elucidate the complex molecular mechanism of anti-Growth effect of the HIV integrase inhibitor, MK-2048 in ATL cells, we attempted to perform gene expression profiling. Four ATL cell lines were cultured with or without MK-2048, then analysed.