Pharmacokinetic characteristics of 86Y-CHX-A’’-DTPA panitumumab and 86Y-CHX-A’’-DTPA-cetuximab.

Pharmacokinetic characteristics of 86Y-CHX-A’’-DTPA-panitumumab and 86Y-CHX-A’’-DTPA-cetuximab injected i.v. via tail vein of female athymic (NCr) nu/nu mice bearing NCI-H226, MSTO-211H and NCI-H2052 tumor xenografts. Data represent the mean values from three to six determinations.*Receptor blocking studies were performed by co-injecting 0.1 mg mAb with the radiotracer. Values obtained from the blocking studies were significantly lower than the unblocked studies (p#Values obtained from 86Y-CHX-A’’-DTPA-panitumumab and 86Y-CHX-A’’-DTPA-cetuximab were significantly different from each other (p