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Transcriptome map of nascent RNA production alterations upon CDK9 and analog senstiveCDK12 and/or CDK13 inhibition (TT-Seq)

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141367
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We performed TT-Seq on MV4;11 WT, CDK12AS/NULL, CDK13AS/AS, #1CDK12AS/NULL;CDK13AS/NULL and #2CDK12AS/NULL;CDK13AS/AS MV4;11 clones treated with 1-NM-PP1 or vehicle for 25 mintues to identify the effect of CDK12 and/or CDK13 on nasenct RNA production. Analog senstive MV4;11 cells were treated with DMSO/1-NM-PP-1 for 20 minutes and then 4sU was added to label nascent RNA for 5 minunts. Nasenct RNA were isolated and sent for sequencing
创建时间:
2020-09-21
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