S25-5 Fab in complex with Chlamydiaceae-specific LPS antigen

S25-5 Fab in complex with Chlamydiaceae-specific LPS antigen Descriptor: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-4-O-phosphono-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Evans, S.V, Haji-Ghassemi, O. Deposit date: 2018-01-16 Release date: 2019-01-09 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude. Biochemistry, 58, 2019S25-5 抗原结合片段（Fragment antigen-binding, Fab）与衣原体科特异性脂多糖（Lipopolysaccharide, LPS）复合物 描述符：3-脱氧-α-D-甘露-2-辛酮糖吡喃糖酸-(2→8)-3-脱氧-α-D-甘露-2-辛酮糖吡喃糖酸-(2→4)-3-脱氧-α-D-甘露-2-辛酮糖吡喃糖酸-(2→6)-2-氨基-2-脱氧-4-O-膦酰基-β-D-葡萄糖吡喃糖-(1→6)-2-氨基-2-脱氧-1-O-膦酰基-α-D-葡萄糖吡喃糖、氯离子、二(羟乙基)醚…… 作者：Evans, S.V.、Haji-Ghassemi, O. 存档日期：2018-01-16 发布日期：2019-01-09 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率1.99埃） 引用文献：《衣原体科特异性单克隆抗体（monoclonal antibody, mAb）S25-23的结合位点细微变化可使抗体-碳水化合物结合亲和力提升一个数量级》，《生物化学》，第58卷，2019年