Study design characteristics of animal studies.

STZ = streptozotocin-induced diabetes (type 1 diabetes); DM2 = type 2 diabetes; SC = subcutaneous; IV = intravenous; IP = intraperitoneal; GFR = glomerular filtration rate; CrCl = 24 hour creatinine clearance; RPF = renal plasma flow; RVR = renal vascular resistance; FF = filtration fraction; KWBW = Kidney weight:body weight ratio; UAE = urine albumin excretion; UPE = urine protein excretion; GV = glomerular volume; GBMT = glomerular basement membrane thickness; ECM = Extracellular matrix area fraction of glomerular cross section; UNa = urinary sodium excretion; UK = urinary potassium excretion; RFR = Renal functional reserve, GSI = Index of glomerulosclerosis, TIFI = Index of tubulointerstitial fibrosis, HbA1c = hemoglobin A1c, Glc = plasma glucose, MAP = mean arterial pressure,* = estimated data extracted electronically from study Figure (see Methods). N reflects the total number of animals in the study overall, not for a particular endpoint.Study design characteristics of animal studies.