The Streptomyces-derived nucleoside Guvermectin simultaneously promotes plant growth and immunity

This study investigates the dual role of the Streptomyces-derived nucleoside Guvermectin (GV) in promoting plant growth and enhancing disease resistance. Multiomics analysis revealed that GV reprograms phenylalanine metabolism, leading to the accumulation of antimicrobial flavonoids. A key UDP-glucosyltransferase (StGTR) and transcription factor (StMYB5) were identified as essential for GV-induced flavonoid production and late blight resistance. Genetic and field experiments confirmed that GV-triggered immunity and growth promotion depend on BAK1 and outperform commercial fungicides in suppressing Phytophthora infestans while improving potato yield. These findings highlight GV’s potential as a natural compound for sustainable crop protection.