Single-cell transcriptomics of mouse small intestinal epithelial cells and intraepithelial lymphocytes. Single-cell transcriptomics of mouse small intestinal epithelial cells and intraepithelial lymphocytes

The goal of this study is to obtain single-cell based transcription data in different intestinal epithelial cell sub-populations. Specifically, we were interested in determining which intestinal epithelial cell subsets express ACE2, the SARS-CoV-2 receptor, and TMPRSS2, a serine protease that facilitates viral spike protein cleavage and virus entry. Overall design: mRNA profiles of uninfected 5-day old 129sv wild type (WT) mice were generated by 10x genomics using Illumina HiSeq 4000