Intestinal colonization of bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease (IBD), however, the causal role of such ectopically c

NIAID Data Ecosystem60

liver RNA sequencing

肝脏转录组

牙周炎骨代谢

Twenty-four mice were randomly divided into four groups: control (Ctrl), periodontitis (PD), high-fat diet (HFD), and HFD with periodontitis (HPD). PD and HPD mice developed periodontitis by week 10,

NIAID Data Ecosystem50

Oral microbiota shapes the gut microbiota, resulting in systemic effects. Oral microbiota shapes the gut microbiota, resulting in systemic effects

口腔-肠道微生物轴

微生物组与代谢组互作

The effect of oral microbiota on the intestinal microbiota has garnered growing attention as a mechanism linking periodontal diseases to systemic diseases. However, the salivary microbiota is diverse

NIAID Data Ecosystem70

Periodontitis salivary microbiota-derived gut microbiota exacerbate colitis by activating CXCL3+ macrophages

口腔-肠道微生物轴

结肠炎机制

To study the role and mechanism of gut microbiota in periodontitis affecting colitis

NIAID Data Ecosystem60