KAMC_COVID-19

We retrospectively collected data of admitted confirmed COVID-19 patients (positive RT-PCR test) to King Abdulaziz Medical City in Riyadh. Starting from the first case, which was on April 2, 2020, till June 18, 2020. We retrieved 5,739 patients records from the EHR system. However, 1513 COVID-19 patients passed the criteria set to be included for mortality endpoint, and 1508 patients passed the inclusion criteria for the ventilatory support requirement endpoint. For ventilatory support requirement, any patient that is lacking one of the following are excluded: 1) confirmed RT-PCR for COVID-19, 2) age >18, 3) CXR, 4) CBC test results, 5) availability of medical history, and 6) Full code status at the time of COVID-19 diagnosis. For mortality inclusion criteria is same as ventilatory support endpoint except that COVID-19 patients who are assigned no-code before the SARS-CoV-2 test are also included. The data include the 36 variables and we below describe how it is obtained and:
1) Gender
2) Age at diagnosis
3) Ventilation support status
4) Vital status
5) Haematocrit
6) Hemoglobin
7) MCHC
8) MCH
9) MCV
10) MPV
11) RBC
12) Platelet_count
13) RDW
14) WBC:
15) CXR zone 1
16) CXR zone 2
17) CXR zone 3
18) CXR zone 4
19) CXR zone 5
20) CXR zone 6
21) CXR zone 7
22) CXR zone 8
23) CXR zone 9
24) CXR zone 10
25) CXR zone 11
26) CXR zone 12
27) cancer_ICD-10_C00-C97
28) chronic_ischaemic_heart_disease_coronary_artery_disease_ICD-10_I25_I250-I259
29) hypertension_ICD-10_I10
30) asthma_ICD-10_J45_J450-J459
31) chronic_obstructive_pulmonary_disease_ICD-10_J44_J440-J449
32) type_2_diabetes_mellitus_ICD-10_E11
33) liver_cirrhosis_ICD-10_K74_K740-K746
34) chronic_viral_hepatitis_B_ICD-10_B181
35) chronic_viral_hepatitis_C_ICD-10_B182
36) chronic_kidney_disease_all_stages_ICD-10N18_N181-N189

Variable 1 is obtained from EHR. Variable 2 obtained from the EHR system as date of birth and converted to age using Covid-19 test date. Variable 3 is filled manually by a physician from the Infectious Disease Department at KAMC, the value MV assigned for mechanical ventilation, NIV for noninvasive ventilation. MV label is assigned if the patient received MV within 30 days of diagnosis. Variable 4: Filled manually by looking at EHR system discharge charts. If the patient is not discharge after 30 days of follow-up and the patient is still alive. The vital status is then reported as Alive. Variables 5-14 are obtained from CBC test results (within 3 days of DX). Variables 15-26, are annotated for CXR severity by four radiologists at KAMC. The images are baseline (within 3 days of DX). The radiologist are blinded to the outcome (mortality, or ventilator support requirement). A value of 0 is assigned for no presence of ground glass opacity (GGO) , a value of 1 for moderate GGO, and a value of 2 for severe manifestation of GGO (see included CXR figure for CXR zones). Variables 27-36 are obtained from the EHR system a value of 0 for disease absence and 1 for disease presence.

本研究对确认为COVID-19的患者（阳性RT-PCR检测）的病历数据进行回顾性收集，数据来源为利雅得的阿卜杜拉国王医学城。收集时间自2020年4月2日的首例病例起，直至2020年6月18日。我们从电子病历系统中检索到5,739位患者的病历记录。然而，仅有1,513名COVID-19患者符合纳入死亡率终点的标准，而1,508名患者符合纳入呼吸支持需求终点的标准。对于呼吸支持需求，任何缺乏以下条件之一的患者均被排除：1) 确诊的COVID-19 RT-PCR检测结果，2) 年龄大于18岁，3) 胸部X光片，4) 全血细胞计数测试结果，5) 医疗史的可用性，以及6) 在COVID-19诊断时的完整代码状态。死亡率纳入标准与呼吸支持需求终点标准相同，但SARS-CoV-2测试前被分配为无代码的COVID-19患者也被纳入。数据包含36个变量，以下将描述其获取方式：

1) 性别
2) 诊断时的年龄
3) 呼吸支持状态
4) 生死状态
5) 红细胞压积
6) 血红蛋白
7) 平均红细胞血红蛋白浓度
8) 平均红细胞体积
9) 平均红细胞血红蛋白量
10) 平均血小板体积
11) 红细胞计数
12) 血小板计数
13) 红细胞分布宽度
14) 白细胞计数
15-26) 胸部X光片各区域的严重程度，由阿卜杜拉国王医学城的四位放射科医师进行标注。图像为基线图像（诊断后3天内）。放射科医师对结果（死亡率或呼吸机支持需求）不知情。对于无磨玻璃样变性的情况赋值为0，中等磨玻璃样变性赋值为1，严重磨玻璃样变性表现赋值为2（见附图中的X光片区域）。27-36) 从电子病历系统中获取，疾病不存在时赋值为0，疾病存在时赋值为1。

变量1从电子病历中获取。变量2从电子病历系统中获取出生日期，并使用COVID-19检测日期转换为年龄。变量3由KAMC感染病科的医师手动填写，MV代表机械通气，NIV代表非侵入性通气。如果在诊断后30天内接受了MV，则分配MV标签。变量4：通过查看电子病历系统出院记录手动填写。如果患者在随访30天后仍未出院且患者仍存活，则生死状态报告为存活。变量5-14从全血细胞计数测试结果（诊断后3天内）获取。变量15-26由KAMC的四位放射科医师对X光片严重程度进行标注。图像为基线图像（诊断后3天内）。放射科医师对结果（死亡率或呼吸机支持需求）不知情。对于无磨玻璃样变性的情况赋值为0，中等磨玻璃样变性赋值为1，严重磨玻璃样变性表现赋值为2（见附图中的X光片区域）。变量27-36从电子病历系统中获取，疾病不存在时赋值为0，疾病存在时赋值为1。