Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris in apo conformation at 3.1 A resolution

Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris in apo conformation at 3.1 A resolution Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Plasma membrane ATP-binding cassette transporter required for the export of a-factor Authors: Schleker, E.S.M, Reinhart, C. Deposit date: 2021-12-18 Release date: 2022-10-26 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proc.Natl.Acad.Sci.USA, 119, 2022分辨率3.1 Å的无配体构象（apo conformation）巴斯德毕赤酵母（Pichia pastoris）来源ATP结合盒转运蛋白（ABC transporter）STE6-2p的冷冻电镜（Cryo-EM）结构。描述符：(3β,14β,17β,25R)-3-[4-甲氧基-3-(甲氧基甲基)丁氧基]螺甾-5-烯，一种负责a因子分泌的质膜ATP结合盒转运蛋白。作者：Schleker, E.S.M、Reinhart, C.。提交日期：2021-12-18；发布日期：2022-10-26；最后修改日期：2024-07-17。实验方法：电子显微镜（3.1 Å）。引用文献：《巴斯德毕赤酵母ABC转运蛋白STE6-2p的结构与功能研究揭示其与甾醇分子存在意外相互作用》，《美国国家科学院院刊》，119卷，2022年。