Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-((2-(1-propylpyrrolidin-3-yl)ethyl)thio)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-((2-(1-propylpyrrolidin-3-yl)ethyl)thio)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone Descriptor: Estrogen receptor, {(1'R)-6'-hydroxy-1'-[4-({[(3S)-1-propylpyrrolidin-3-yl]methyl}sulfanyl)phenyl]-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl}(phenyl)methanone Authors: Hancock, G.R, Young, K.S, Hosfield, D.J, Joiner, C, Sullivan, E.A, Yildz, Y, Laine, M, Greene, G.L, Fanning, S.W. Deposit date: 2022-07-28 Release date: 2022-11-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ Breast Cancer, 8, 2022

与(6'-羟基-1'-(4-((2-(1-丙基吡咯烷-3-基)乙基)硫基)苯基)-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基)(苯基)甲酮形成复合物的雌激素受体α（Estrogen Receptor Alpha）配体结合域
描述：雌激素受体，{(1'R)-6'-羟基-1'-[4-({[(3S)-1-丙基吡咯烷-3-基]甲基}硫基)苯基]-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基}(苯基)甲酮
作者：Hancock, G.R、Young, K.S、Hosfield, D.J、Joiner, C、Sullivan, E.A、Yildz, Y、Laine, M、Greene, G.L、Fanning, S.W
提交日期：2022-07-28
发布日期：2022-11-09
最后修改日期：2023-10-25
实验方法：X射线衍射（1.7埃）
引用文献：非经典异喹啉类选择性雌激素受体调节剂（Selective Estrogen Receptor Modulators, SERMs）在雌激素受体阳性（ER+）乳腺癌细胞中引发氟维司群样转录程序。《NPJ乳腺癌》，8卷，2022年