Formal Synthesis of (+)-Lasubine II and (−)-Subcosine II via Organocatalytic Michael Addition of a Ketone to an α‑Nitrostyrene
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https://figshare.com/articles/dataset/Formal_Synthesis_of_Lasubine_II_and_Subcosine_II_via_Organocatalytic_Michael_Addition_of_a_Ketone_to_an_Nitrostyrene/2112340
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资源简介：
The first examples of an organocatalytic
Michael addition of a
ketone to in situ generated α-nitrostyrenes are reported. A
suitably functionalized γ-nitroketone obtained from the organocatalyzed
Michael addition was converted into (+)-2-epi-lasubine
II, the immediate synthetic precursor of (+)-lasubine II and (−)-subcosine
II (enantiomers of the natural quinolizidine alkaloids). Two of the
three stereocenters in (+)-2-epi-lasubine II are
set by the Michael reaction.
创建时间：
2016-02-12
