GAS Study: A multi-site randomised controlled trial comparing regional and general anaesthesia for effects on neurodevelopmental

This dataset contains de-identified participant level data from the GAS trial, an international, multicentre, randomised controlled equivalence study examining neurodevelopmental outcomes in children exposed to different anaesthetic techniques in infancy. The dataset includes baseline demographic and clinical characteristics, peri-operative and anaesthetic exposure information, and longitudinal neurodevelopmental assessment data collected up to 5 years of age.

Data are structured at the individual participant level and support comparison between children who received general anaesthesia and those who received awake regional anaesthesia during infancy. Outcome data include standardised neurodevelopmental and cognitive assessment measures collected at prespecified follow-up time points.

Prior to releasing any data the following are required: a data access agreement must be signed between relevant parties, the GAS Trial Steering Committee must see and approve the analysis plan describing how the data will be analysed, there must be an agreement around appropriate acknowledgement and any additional costs involved must be covered. Data will only be shared with a recognised research institution which has approved the proposed analysis plan.

DOI: 10.1016/S0140-6736(18)32485-1 External Link
DOI: 10.1097/ALN.0000000000000709
DOI: 10.1097/ALN.0000000000000708
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