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Developmental maturation of hematopoietic stem and progenitor cells mediated by Lin28b/let-7/Cbx2

NIAID Data Ecosystem2026-03-13 收录

造血分化

多梳抑制复合物标记

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP334820 数据链接链接失效反馈

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资源简介：

This study encompasses two human cell lines used to profile polycomb repressive complex markers during hematopoietic maturation.

应用场景：

创建时间：

2022-02-08

DNA甲基化

造血分化

Supplementary figures and supplementary data tables from MethylationEPIC arrays (Tejedor et al), plus a compiled dataset including raw methylation intensities, processed β-values and Phenotypic data f

DataCite Commons2024-10-09 更新110

Additional file 2: of Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells

造血分化

细胞分化诱导

Table S7. Q-PCR primers used in this study (XLSX 11 kb)

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Different mutant RUNX1 oncoprotein classes program alternate haematopoietic differentiation trajectories [ChIP-seq2]. Different mutant RUNX1 oncoprotein classes program alternate haematopoietic differentiation trajectories [ChIP-seq2]

造血分化

ChIP-seq

Mutations of the hematopoietic master regulator RUNX1 cause acute myeloid leukaemia, familial platelet disorder and other haematological malignancies whose phenotypes and prognoses depend on the class

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Characterization of hematopoietic differentiation cultures by CITE-seq

造血分化

单细胞测序

Seurat object with single-cell CITE-seq object characterizing the culture conditions used in Frömel et al. (2025), Design principles of cell state specific enhancers in hematopoiesis . Primary h

DataCite Commons2025-06-01 更新60

Top 200 most variable genes per donor determined by CALISTA and used for cell cluster identification.

细胞基因表达

造血分化

Note that the list for the 2 donors is almost identical (the first 80 genes are in the same order). The only gene on the list that plays a key role in hematopoietic differentiation is RUNX1. (CSV)

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Developmental maturation of hematopoietic stem and progenitor cells mediated by Lin28b/let-7/Cbx2

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