MOESM3 of Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes

Additional file 3. Comparison of wild-type and disease-associated mutant PAPA scores. For all disease associated mutants in the ClinVar database, mutant sequences were generated by incorporating the indicated amino acid substitution at the appropriate position and re-scored using the modified PAPA algorithm. For each variant, both wild-type and mutant aggregation propensity scores are indicated, as well as the difference between mutant and wild-type scores. For each variant, the associated disease phenotype annotation is also included. PLAAC predictions are also included, as indicated for Additional file 2