Osteoarthritis Initiative

骨关节炎倡议 (OAI) 是一项纵向队列研究，旨在调查整个疾病范围内膝关节骨关节炎的自然史。OAI包括临床数据和生物样本。收集的数据包括膝关节症状和功能 (使用西安大略和麦克马斯特大学关节炎指数 (WOMAC) 和膝关节损伤和骨关节炎结果评分 (KOOS)，髋关节和其他关节症状，一般生活质量，身体表现，膝关节检查，危险因素，健康行为，社会心理措施，以及服用的药物和补充剂。
在招募时，OAI共招募了4,796名年龄在45至79岁之间的参与者。收集的生物样本包括血液，尿液，DNA和淋巴细胞。在整个研究过程中收集的图像包括基线和年度双侧膝关节x射线以及双侧膝关节MRI和其他关节成像 (例如，髋关节，骨盆和手部x射线; 大腿MRI; 以及用于膝关节对齐的全肢MRI)。在基线的电话筛查期间收集数据; 12、24、36、48、72、96个月的随访门诊访视; 在18和30个月的中期访视期间; 以及在60个月、84个月和108个月进行问卷调查。

The Osteoarthritis Initiative (OAI) is a longitudinal cohort study designed to investigate the natural history of knee osteoarthritis across the full disease spectrum. OAI includes both clinical data and biological specimens. Collected data encompass knee symptoms and function (assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Knee Injury and Osteoarthritis Outcome Score (KOOS)), hip and other joint symptoms, general quality of life, physical performance, knee examinations, risk factors, health behaviors, psychosocial measures, as well as medications and supplements used by participants. At study recruitment, a total of 4,796 participants aged 45 to 79 years were enrolled in the OAI. Collected biological specimens include blood, urine, DNA, and lymphocytes. Imaging data gathered throughout the study include baseline and annual bilateral knee radiographs, bilateral knee MRI, and imaging of other joints (e.g., hip, pelvic, and hand radiographs; thigh MRI; and full-limb MRI for knee alignment assessment). Data were collected during a baseline telephone screening, follow-up clinic visits at 12, 24, 36, 48, 72 and 96 months, mid-term visits at 18 and 30 months, and via questionnaires administered at 60, 84 and 108 months.

搜集汇总

背景与挑战

背景概述

Osteoarthritis Initiative（OAI）是一个专注于膝关节骨关节炎研究的纵向队列数据集，包含4,796名45至79岁参与者的临床评估、生物样本和影像数据，旨在全面分析疾病自然史。数据覆盖从基线到108个月的多个时间点，涉及症状、功能评分、生活质量等多维度信息，由纽约大学于2004年发布，适用于骨关节炎的长期研究和分析。