Data_Sheet_1_Association Between Single Nucleotide Polymorphisms in PPARA and EPAS1 Genes and High-Altitude Appetite Loss in Chinese Young Men.PDF

Appetite loss is a common symptom that occurs in high altitude (HA) for lowlanders. Previous studies indicated that hypoxia is the initiating vital factor of HA appetite loss. PPARA, EPAS1, EGLN1, HIF1A, HIF1AN, and NFE2L2 play important roles in hypoxic responses. We aimed to explore the association of these hypoxia-related gene polymorphisms with HA appetite loss. In this study, we enrolled 416 young men who rapidly ascended to Lhasa (3700 m) from Chengdu (

食欲减退是低地人进入高海拔地区（HA）时常出现的一种常见症状。既往研究表明，缺氧是高海拔食欲减退的启动性生命因子。PPARA、EPAS1、EGLN1、HIF1A、HIF1AN以及NFE2L2在缺氧反应中发挥着重要作用。本研究旨在探讨这些缺氧相关基因多态性与高海拔食欲减退之间的关联。在本研究中，我们招募了416名从成都（海拔约1500米）迅速攀升至拉萨（海拔3700米）的年轻男性。