Development of Cognitive and Imaging Biomarkers Predicting Risk of Self-Blaming Bias and Recurrence in Major Depression

This data-set consists of fully anonymised task-based fMRI using a value-related moral sentiments task which probes emotions related to self-blame such as guilt and blaming others, such as anger, structural 3 dimensional T1 weighted and resting-state fMRI data for remitted MDD and Healthy Control participants taking part in our studies. Data sharing is stipulated by our MRC-approved data management plan. Basic anonymised clinical and demographic descriptors are also available.In addition to the anonymised clinical data, the dataset also includes anonymised results of standard questionnaires, phenomenological psychopathology and neurocognitive tasks probing moral sentiments, emotional memory, action tendencies, and social knowledge which were described in our papers, alongside some unpublished data which can be used after seeking permission from the chief investigator. Data from the following publications are entailed in the dataset which should be cited when using the different aspects of the data:-Gethin J.A., Lythe K.E., Workman C.I., Mayes A., Moll J., Zahn R. Early life stress explains reduced positive memory biases in remitted depression. Eur Psychiatry (2017) 45:59-64: Early life event classification and emotional recognition memory test-Workman C.I., Lythe K.E., McKie S., Moll J., Gethin J.A., Deakin J.F.W., Elliott R., Zahn R. A novel resting-state functional MRI signature of resilience to recurrent depression. Psychological Medicine (2017) 47: 597–607: Resting state fMRI data with prospective clinical follow-up of remitted MDD participants over 14 months-Workman C.I., Lythe K.E., McKie S., Moll J., Gethin J.A., Deakin J.F.W., Elliott R., Zahn R. Subgenual cingulate-amygdala functional disconnection and vulnerability to melancholic depression. Neuropsychopharmacology (2016) https://doi.org/10.1038/npp.2016.8: Resting state fMRI cross-sectional MDD vs Healthy Control comparisons-Lythe K.E., Moll J., Gethin J.A., Workman C.I., Green S., Lambon Ralph