HIV-1 Protease WT (NL4-3) with Inhibitor NR01-141

HIV-1 Protease WT (NL4-3) with Inhibitor NR01-141 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, Protease, SULFATE ION Authors: Lockbaum, G.J, Kaur, J, Shaqra, A.M, Schiffer, C.A. Deposit date: 2025-10-07 Release date: 2025-12-24 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. Eur.J.Med.Chem., 304, 2025携带抑制剂NR01-141的HIV-1蛋白酶野生型（NL4-3） 描述物：(3R,3aS,6aR)-六氢呋喃并[2,3-b]呋喃-3-基 [(2S,3R)-3-羟基-4-{[(1S)-1-羟基-2,3-二氢-1H-茚-5-磺酰基](2-甲基丙基)氨基}-1-苯基丁烷-2-基]氨基甲酸酯、蛋白酶、硫酸根离子 作者：Lockbaum, G.J.、Kaur, J.、Shaqra, A.M.、Schiffer, C.A. 提交日期：2025-10-07 发布日期：2025-12-24 最后修改日期：2026-01-07 实验方法：X射线衍射（1.96 Å） 引用文献：《含手性羟乙基苯与茚满醇作为P2'配体的氟化HIV-1蛋白酶抑制剂，对耐药变异株具有强效活性》，Eur.J.Med.Chem., 304, 2025