Transcriptomic alterations in response to citrinin in human neuronal cells SH-SY5Y

Mycotoxin citrinin (CTN) is a contaminant widely found in foods, feeds, and fermented health supplements. To investigate the potential neurotoxic effect of CTN, RNA-seq was performed on human neuroblastoma cells SH-SY5Y exposed to 0, 10, and 20 µM CTN for 72 h. The transcriptomic profile revealed novel underlying mechanisms of CTN neurotoxicity, providing useful information for risk assessment of consuming CTN-contaminated grains and its commercial food products. Overall design: RNA-seq analysis was performed for CTN-exposed samples. Human neuroblastoma cells SH-SY5Y were treated with vehicle (CTN0), 10 µM CTN (CTN10), and 20 µM CTN (CTN20) for 72 h. Three replicates were performed for each sample.