The co-crystal structure of Severe Acute Respiratory Syndrome Coronavirus 3C Like Protease with aldehyde M14

The co-crystal structure of Severe Acute Respiratory Syndrome Coronavirus 3C Like Protease with aldehyde M14 Descriptor: (2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide, Replicase polyprotein 1a Authors: Wang, H, Shang, L.Q. Deposit date: 2020-01-02 Release date: 2020-05-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.939 Å) Cite: Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease. Acs Catalysis, 10, 2020

严重急性呼吸综合征冠状病毒3C样蛋白酶（3C-like Protease）与醛类配体M14的共晶体结构。配体结构描述符：(2S)-4-甲基-N-[(2S)-1-氧代-3-[(3S)-2-氧代吡咯烷-3-基]丙-2-基]-2-[[(E)-3-苯基丙-2-烯酰]氨基]戊酰胺；该蛋白酶为复制酶多聚蛋白1a的组成部分。作者：Wang, H、Shang, L.Q.；保藏日期：2020-01-02，发布日期：2020-05-27，最后修改日期：2023-11-29；结构解析方法：X射线衍射法（X-RAY DIFFRACTION，分辨率1.939埃）；引用文献：《中东呼吸综合征3C样蛋白酶与严重急性呼吸综合征3C样蛋白酶的催化机制综合解析》，刊载于《ACS催化》2020年第10卷。