CBR9379 bound Open2 Eco-ePEC: Cryo-EM structure of Eco RNAP his-elemental paused elongation complex with an open active site (open TL, SI3 and RH-FL)

CBR9379 bound Open2 Eco-ePEC: Cryo-EM structure of Eco RNAP his-elemental paused elongation complex with an open active site (open TL, SI3 and RH-FL) Descriptor: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, CHAPSO, DNA-directed RNA polymerase subunit alpha, ... Authors: Dhingra, Y, Darst, S.A. Deposit date: 2026-01-27 Release date: 2026-06-24 Last modified: 2026-07-15 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: RNA polymerase inhibitors reveal active-site motions essential for the nucleotide addition cycle. Proc.Natl.Acad.Sci.USA, 123, 2026