Proportion of MS patients and HC in different risk categories and median wGRS with interquartile range (IQR) of MS and HC in each model (only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations).

In brief, the genotype at MS associated loci was used to assign each individual to the categories of risk identified using the simulated population from table 1. Furthermore, a weighted genetic risk (wGRS) was calculated by multiplying the number of risk alleles by the weight of each SNP and then taking the sum across all associations (see methods).