Microbial oral-gut translocation in advanced chronic liver disease is linked to exacerbation of intestinal barrier dysfunction and hepatic fibrosis

Microbiome alterations are associated with advanced chronic liver disease (ACLD), but mechanisms remain unclear. We analyzed saliva and fecal samples from ACLD patients, healthy controls, and septic controls. ACLD patients were stratified by disease stage (cACLD, AD, ACLF)