The most significant contact occurrences in protein-protein interfaces derived from protein-protein complexes.

The residue pairs presenting most significant p-values (top 10 from the favored and excluded categories each) are listed here. It should be noted that the data were derived from all residues of the complex, and that the surface propensity of the residues is implicitly included. Near absence of the hydrophobic residues in the top scoring pairs highlights the fact that from a purely sequence point of view hydrophobic pairs may not be the best interface candidates. However, if only the surface residues were considered (using structure information), situation might be different.