Expression data from childhood obesity

In the past few decades, the prevalence of overweight and obesity has sharply increased in children and adolescents. Childhood obesity life are associated with increased risk of cardiovascular disease (CVD), diabetes mellitus, metabolic syndrome, sleep disturbances and certain cancers in adulthood. Childhood obesity has become a serious global public health challenge. Long noncoding RNAs (lncRNAs) have an important role in adipose tissue function and energy metabolism homeostasis, and abnormalities may lead to obesity. We used microarrays to detail the differential expression profile of lncRNAs and mRNAs in obese children compared with non-obese children. Abdomen subcutaneous adipose tissue of children were selected for RNA extraction and hybridization on Affymetrix microarrays. To obtain the differential expression profile of lncRNAs and mRNAs expression profiles, we selected 4 obese children (sample number 32, 35, 37, 38) and 4 non-obese children (sample number 21, 22, 26, 27).