Pathways/functions regulated on gene level.

The three most significantly upregulated and the three most significantly downregulated pathways/functions in skeletal muscle from people with type 2 diabetes and first degree relatives. Results were obtained employing the program GenMAPP/MAPPFinder. Criteria were set as described in the Methods section. Pathways found to be significantly altered after correction for multiple testing (adjusted p-value) are depicted in bold writing. Interestingly, the insulin signaling pathway was the highest ranked upregulated pathway in the first degree relative group, whereas it was found to be the top ranked downregulated pathway in people with type 2 diabetes.