CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1

CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, ... Authors: Zhou, B, Zhao, H, Gao, Y, Chen, X, Zhang, T, He, J, Xiong, X. Deposit date: 2024-02-19 Release date: 2025-03-19 Last modified: 2026-04-01 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis Nat Commun, 16, 2025结核分枝杆菌（Mycobacterium tuberculosis, M. tuberculosis）ClpC1P1P2复合物与硼替佐米（bortezomib）结合的冷冻电镜（CryoEM）结构，构象1。描述项：腺苷5'-二磷酸（Adenosine-5'-diphosphate, ADP）、腺苷5'-三磷酸（Adenosine-5'-triphosphate, ATP）、ATP依赖型Clp蛋白酶ATP结合亚基ClpC1等。作者：Zhou B、Zhao H、Gao Y、Chen X、Zhang T、He J、Xiong X。沉积日期：2024-02-19；发布日期：2025-03-19；最后修改日期：2026-04-01。实验方法：电子显微镜（分辨率2.81埃）。引用文献：《结核分枝杆菌酪蛋白溶解伴侣-蛋白酶系统的硼替佐米诱导激活的结构解析》，《自然·通讯》，2025年，第16卷。