Global profiling of lysine lactylation in prostate cancer cells

Lysine lactylation (Kla) is a recently identified post-translational modification derived from lactate that regulates diverse biological processes. Although Kla has been studied in several cancers, its role in prostate cancer (PC) remains unclear. We identified 681 Kla sites across 379 proteins, with modifications predominantly located in nuclear and cytoplasmic proteins. Enrichment analysis indicatedrevealed Kla involvement in mRNA splicing, chromatin organization, and glycolysis/gluconeogenesis.