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Stat6 mediated regulation of transcription to initiate Th2 program in human T cells. Stat6 mediated regulation of transcription to initiate Th2 program in human T cells

NIAID Data Ecosystem2026-03-06 收录

Th2细胞分化

Stat6转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA119249 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2010-06-25

Th2细胞分化

4m8c药物效应

Study was designed to compare the transcriptome of Th2 cells in presence or absence of 4m8c. Murine splenic naive T helper cells were activated in presence of anti-CD3e, anti-CD28 antibodies and IL4 a

NIAID Data Ecosystem80

Overexpression of RORA in primary mouse in vitro Th2

Th2细胞分化

RORA基因调控

Naive CD4 T cells were taken from spleens of wild-type mice, and activated with CD3/CD28. IL4 was added to induce Th2. The cells were transduced with retrovirus to overexpress RORA vs control. Three d

NIAID Data Ecosystem60

Gene_expression_during_Th2_differentiation_in_RORA_knockout. Gene_expression_during_Th2_differentiation_in_RORA_knockout

Th2细胞分化

细胞基因表达

Naïve CD4+ T helper (Th) cells differentiate into distinct lineages to achieve successful adaptive immune responses to diverse categories of pathogens. However, the molecular regulation of this develo

NIAID Data Ecosystem50

Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region

Th2细胞分化

转录因子协同作用

The T helper type 2 (Th2) locus control region (LCR) regulates Th2 cell differentiation. Several transcription factors bind to the LCR to modulate the expression of Th2 cytokine genes, but the molecul

NIAID Data Ecosystem60

BRD4-PRC2 Represses Transcription of T-helper 2-Specific Negative Regulators during T-cell Differentiation

Th2细胞分化

表观遗传转录调控

BRD4 is a well-recognized transcriptional activator, but how it regulates gene transcriptional repression in a cell-type specific manner has remained elusive. In this study, we report that BRD4 works

NIAID Data Ecosystem60

Stat6 mediated regulation of transcription to initiate Th2 program in human T cells. Stat6 mediated regulation of transcription to initiate Th2 program in human T cells

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