A Randomized, Three-Arm, Dose-Blinded, Parallel-Group Study to Determine the Effect of Avonex® Dose Titration on the Severity and Incidence of Interferon Beta-1a-Related Flu Like Symptoms in Healthy Volunteers

The primary objective of the study is to determine whether titration of Avonex reduces the
severity of flu-like symptoms (FLS). Secondary objectives of this study are to determine
whether titration of Avonex reduces the incidence of FLS and to evaluate the overall safety
and tolerability of Avonex intramuscular (IM) injections.