N6-methyladenosine (m6A) RNA modification plays important roles in the governance of gene expression and is temporally regulated in different cell states. In contrast to global m6A profiling in bulk s
The goals of this study are to compare the downstream m6A modification changes and transcriptional changes in AML cells with or without METTL3 overexpression.mRNA profiles of METTL3-ovexpressing THP-1
Additional file 14: Table S13. Differentially expressed genes containing hypermethylated m6A peaks in strawberry fruit at RS1 stage compared to those at S6 stage.
RNA was isolated from control and Mettl3 cKO mouse testes using the TRIzol (Invitrogen) reagent by following the manufactures's instructions. For all samples the RNA integrity was checked using an Agi
We here report ALKBH5, a m6A RNA demethylase, as a crucial oncogene in multiple myeloma (MM). Using various MM models, we demonstrated a critical requirement of ALKBH5 for MM cell proliferation in vit
