Owen1998 - tumour growth model

Owen1998 - tumour growth model
Deterministic model for the early,
avascular growth of a tumour, concentrating on the inhibitory
effect of macrophages.

This model is described in the article:

Modelling the macrophage
invasion of tumours: effects on growth and composition.

Owen MR, Sherratt JA.
IMA J Math Appl Med Biol 1998 Jun;
15(2): 165-185
Abstract:

Even in the early stages of their development, tumours are
not simply a homogeneous grouping of mutant cells; rather, they
develop in tandem with normal tissue cells, and also recruit
other cell types including lymphatic cells and the endothelial
cells required for the development of a blood supply. It has
been repeatedly seen that macrophages form a significant
proportion of the tumour mass, and that they can have a variety
of effects upon the tumour, leading to a delicate balance
between growth promotion and inhibition. This paper develops a
model for the early, avascular growth of a tumour,
concentrating on the inhibitory effect of macrophages due to
their cytolytic activity. It is shown that such an immune
response is not sufficient to prevent growth, due to it being a
second-order process with respect to the density of the tumour
cells present. However, the presence of macrophages does have
important effects on the tumour composition, and the authors
perform a detailed bifurcation analysis of their model to
clarify this. An extended model is also considered which
incorporates addition of exogenous chemical regulators. In this
case, the model admits the possibility of tumour regression,
and the therapeutic implications of this are discussed.

This model is hosted on
BioModels Database
and identified by:
BIOMD0000000670.
To cite BioModels Database, please use:
Chelliah V et al. BioModels: ten-year
anniversary. Nucl. Acids Res. 2015, 43(Database
issue):D542-8.

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