Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Descriptor: 1,2-ETHANEDIOL, N-(4-{[4-(pyrrolidin-1-yl)piperidin-1-yl]sulfonyl}benzyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine 1,1-dioxide, Nicotinamide phosphoribosyltransferase, ... Authors: Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. Deposit date: 2013-07-26 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013

基于片段的反式-2-(吡啶-3-基)环丙烷羧酸衍生酰胺类化合物作为人类烟酰胺磷酸核糖转移酶（Nicotinamide Phosphoribosyltransferase, NAMPT）强效抑制剂的鉴定
描述符：1,2-乙二醇、N-(4-{[4-(吡咯烷-1-基)哌啶-1-基]磺酰基}苄基)-2H-吡啶并[4,3-e][1,2,4]噻二嗪-3-胺 1,1-二氧化物、烟酰胺磷酸核糖转移酶（NAMPT）等
作者：Giannetti, A.M、Zheng, X、Skelton, N、Wang, W、Bravo, B、Feng, Y、Gunzner-Toste, J、Ho, Y、Hua, R、Wang, C、Zhao, Q、Liederer, B.M、Liu, Y、O'Brien, T、Oeh, J、Sampath, D、Shen, Y、Wang, L、Wu, H、Xiao, Y、Yuen, P、Zak, M、Zhao, G、Dragovich, P.S.
存档日期：2013-07-26
发布日期：2013-09-25
最后修改日期：2024-02-28
研究方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.55埃）
引用文献：《1H-吡唑并[3,4-b]吡啶-5-羧酸衍生酰胺类化合物作为人类烟酰胺磷酸核糖转移酶（NAMPT）强效抑制剂的鉴定》，《Bioorg.Med.Chem.Lett.》，2013年，第23卷