Microarray mRNA expression profiling in Stat5b knockdown pancreatic beta cell line
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85496
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资源简介：
Stat5b gene is located at IDD4 type 1 diabetes susceptibility interval, and is mutated in NOD mice. This mutation has been linked to diabetes with strong association with autoimmune aetiology. We have treated MIN6 pancreatic beta cell line with Stat5b siRNA and analyzed the differential expression profile in control siRNA treated versus Stat5b siRNA treated cells in an effort to understand the role of Stat5b in diabetes. MIN6 cells were treated with control siRNA or Stat5b siRNA for 72 hours, followed by prolactin stimulation. The cells were trypsinized and total RNA isolated using miRNeasy Mini Kit (Qiagen). The mRNA differential expression was compared using Illumina microarray platform.
创建时间：
2023-01-01
