Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid,

NIAID Data Ecosystem70

Cytotoxicity of Ruthenium–Arene Complexes Containing β‑Ketoamine Ligands

金属配合物抗癌

癌细胞耐药性

New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing β-ketoamine ligands L′ (HL′ in general; in detail, HLph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)meth

NIAID Data Ecosystem50

Transcriptional profiling of parental mouse erythroleukemia (MEL) and HMBA-resistant (MEL-R) cells

癌细胞耐药性

细胞分化调控

We have previously isolated a murine erythroleukemia cell line refractive to re-enter a cell differentiation program as opposite to the progenitor cell line. We use RNA-seq to identify differentially

NIAID Data Ecosystem70

Identifying States of Collateral Sensitivity During the Evolution of Therapy Resistance in Ewing’s Sarcoma Poster for 2019 AACR

癌细胞耐药性

化疗药物敏感性分析

Two Ewing's sarcoma cell lines were evolved in the standard chemotherapy treatment given to patients. After each dose of chemotherapy treatment, drug sensitivity profiles were captured on each cell li

NIAID Data Ecosystem50

IC<sub>50</sub> of CTL and SorR cells towards sorafenib treatment.

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