Enantioselective Total Syntheses of (+)-Hostmanin A, (−)-Linderol A, (+)-Methyllinderatin and Structural Reassignment of Adunctin E

A one-step protocol has been developed
for the enantioselective
synthesis of hexahydrodibenzofuran derivatives using a modified Friedel–Crafts
reaction. The developed method was applied to the synthesis of a series
of natural products including (+)-hostmanin A, (+)-methyllinderatin,
and (−)-linderol A. The synthetic and spectroscopic data investigations
led to the structural reassignment of natural product adunctin E,
which was further confirmed by single-crystal X-ray analysis.