Fine-tuned repression of Drp1 driven mitochondrial fission primes a 'stem/progenitor-like state' to accelerate neoplastic transformation

Mitochondria based priming of a stem/progenitor-like state involves fine-tuned repression of the master regulator of mitochondrial fission, Drp1, and drives carcinogen induced transformation in a keratinocyte model Overall design: Comparison of scRNAseq data of parental HaCaT ketatinocyte line, their TCDD (1nM and 10nM) driven transformed counterparts, and after expression of control, weak and strong Drp1 shRNA.