Cryo-EM structure of dexmedetomidine-bound alpha-2A-adrenergic receptor in complex with heterotrimeric Gi-protein

Cryo-EM structure of dexmedetomidine-bound alpha-2A-adrenergic receptor in complex with heterotrimeric Gi-protein Descriptor: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Endolysin,Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Lou, J.S, Su, M, Wang, J, Do, H.N, Miao, Y, Huang, X.Y. Deposit date: 2024-06-19 Release date: 2024-09-11 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Distinct binding conformations of epinephrine with alpha- and beta-adrenergic receptors. Exp.Mol.Med., 56, 2024本数据集为与异三聚体G蛋白（heterotrimeric G-protein）结合的右美托咪定（dexmedetomidine）靶向结合α2A肾上腺素能受体（alpha-2A-adrenergic receptor）的冷冻电镜（Cryo-EM）结构。 描述项：4-[(1S)-1-(2,3-二甲基苯基)乙基]-1H-咪唑、内溶素（Endolysin）、α2A肾上腺素能受体、鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）…… 作者：Lou, J.S、Su, M、Wang, J、Do, H.N、Miao, Y、Huang, X.Y. 存入日期：2024-06-19 发布日期：2024-09-11 最后修改日期：2024-10-16 实验方法：电子显微镜（3.2埃） 引用文献：《肾上腺素与α及β肾上腺素能受体的独特结合构象》，《实验与分子医学》（Exp.Mol.Med.），第56卷，2024年