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Increased antigen cross-presentation but impaired cross-priming after activation of PPARÎ³

ChEBI2010-05-08 更新2026-07-21 收录

抗原交叉呈递

PPARγ免疫调节

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-15616 数据链接链接失效反馈

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资源简介：

Increased antigen cross-presentation but impaired cross-priming after activation of PPARÎ³

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创建时间：

2010-05-08

病原免疫逃逸机制

抗原交叉呈递

During cross-presentation, exogenous antigens (i.e. intracellular pathogens or tumor cells) are internalized and processed within the endocytic system and also by the proteasome in the cytosol. Then,

NIAID Data Ecosystem90

Proteasomal degradation within endocytic organelles mediates antigen cross-presentation

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MHC-I类抗原处理

During MHC-I-restricted antigen processing, peptides generated by cytosolic proteasomes are translocated by the Transporter associated with Antigen Processing (TAP) into the endoplasmic reticulum, whe

NIAID Data Ecosystem40

Tumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer

肿瘤免疫逃逸

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Tumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer

integrated proteome resources30

Modular expression analysis reveals functional conservation between human Langerhans Cells and mouse cross-priming dendritic cells

免疫细胞功能

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Characterization of functionally distinct Dendritic Cell (DC) subsets in mice has fueled interest in whether analogous counterparts exist in humans. Transcriptional modules of coordinately expressed g

NIAID Data Ecosystem80

Discovery of New Nanomolar Selective IRAP Inhibitors

抑制剂设计

抗原交叉呈递

Among the M1 family of oxytocinase aminopeptidases, insulin-regulated aminopeptidase IRAP, is an emerging drug target implicated in various biological pathways and particularly in MHC-I antigen presen

Figshare2025-02-27 更新30

Increased antigen cross-presentation but impaired cross-priming after activation of PPARÎ³

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