Results of multivariable MR with 3 lipid traits, BMI, and AaM, as exposures and BC risk as outcome.

Results are from 4 separate multivariable MR experiments: 3 with outcome summary statistics from independent subsets of the BC data set (BC_Onco, Oncoarray; BC_iCoGS, iCOGS; or BC_GWAS, GWAS), or using the BCAC meta-analysis summary statistics (BC_Meta). Lipid summary statistics are from MVP. Before/after pruning: results from MR before or after pruning for instrument heterogeneity; Exposure: trait used as exposure; Outcome: BC summary statistics used for the outcome; N_SNPs: number of genetic instruments used in MR test; CI_95_L: lower bound of 95% CI; CI_95_U: upper bound of 95% CI; P: P-value of MR test. AaM, age at menarche; BC, breast cancer; BCAC, Breast Cancer Association Consortium; BMI, body mass index; CI, confidence interval; GWAS, genome-wise association study; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MR, Mendelian randomization; MVP, Million Veteran Program; TG, triglyceride. (XLSX)