Trifluoromethylation of α‑Haloketones
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Trifluoromethylation_of_Haloketones/2481847
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The C–X bond (X = Br, Cl) of α-haloketones is smoothly trifluoromethylated with the fluoroform-derived CuCF3 reagent recently developed in our laboratories. This is the first nucleophilic α-trifluoromethylation reaction of carbonyl compounds and a rare example of CF3–C(sp3) coupling. The transformation employs only low-cost chemicals and cleanly occurs in up to 99% yield at room temperature, thereby providing an unprecedentedly easy entry to valuable 2,2,2-trifluoroethylketones.
创建时间：
2016-02-20
