Loss of Rab22a prevents Angiotensin II-induced Hypertension and vascular dysfunction by inhibiting AT1R recyling

The goals of this study is to compare the differently expressed genes in abdominal aorta of Rab22a KO mice and Rab22a WT mice with or without Angiotensin II treatment for 14 days at the concentration of 500ng/kg/min.The mice (n=20) were randomly divided into 4 groups:WT+AngII,WT+NS,KO+AngII,KO+NS (n = 5 for each group). Mice in WT+NS and KO+NS groups were infused with saline or 500 ng/kg/min of WT+AngII and KO+AngII respectively. Then the abdominal aorta were used to identify differentially expressed genes among different groups. Overall design: RNA sequencing was performed with abdominal aorta of mice in 4 groups (WT+AngII,WT+NS,KO+AngII,KO+NS,n = 5 for each group) to identify the differently expressed genes and related pathway.